We are seeking to appoint an Early Stage Researcher (ESR, PhD fellow) within the FOIE GRAS European Training Network sponsored by the European Union H2020 Marie Sklodowska Curie Actions. ESR will participate in a research project aiming at identifying the clinical, metabolic and molecular abnormalities associated with Non-Alcoholic Fatty Liver Disease (NAFLD), such as early changes in mitochondrial function, biogenesis and oxidative stress, and its regulation in different stages of the disease by using animal models for NAFLD. The research will be conducted at the Nencki Institute of Experimental Biology (NENCKI), Poland, commencing in June 2017. Funding is initially available for three years and ESR is expected to be enrolled in a PhD programme.
A key objective of the FOIE GRAS network is to better understand the metabolic mechanisms and treatment behind NAFLD. The project will investigate the role of mitochondrial oxidative stress in NAFLD and the signalling pathways associated with stress responses. Multiple antioxidants with different targeting features will be used during this work. The work will be performed in both cell and animal models.
Research will include methodologies associated to the next generation of animal models for NAFLD, their characterization, as well as analyses of hepatic mitochondrial function, biogenesis, quality control mechanisms (e.g. autophagy, mitophagy) as well as general oxidative stress. The fellow will be trained in medicinal chemistry, namely in attained structural-activity-relationship studies that include chemical synthesis/purification/ characterization methods and biological data acquisition (three distinct biological models will be used to test the different mitochondrial-directed antioxidants). The post-holder will have some scope to adapt the project based on his/her interests.
The post-holder will complete a research project under the supervision of Dr. Mariusz Wieckowski at NENCKI, with additional supervision of Dr. John Jones and Dr. Paulo Oliveira at the Center for Neuroscience and Cell Biology and University of Coimbra, Portugal, and Dr. Fernanda Borges from University of Porto (UPORTO), Portugal.
The post-holder will be a member of the ETN FOIE GRAS (GA No. 722619), which comprises 10 beneficiary institutions and 4 associated partners from industry and clinical practice in 7 countries. Prospective candidates are encourage to have a look at the other available ESR projects in the network (13 in total, see FOIE GRAS’ website) and indicate up to 3 projects in order of preference in their applications.